Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-01-22
1986-05-13
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549463, A61K 3134, C07D30700
Patent
active
045887438
ABSTRACT:
7-Oxabicycloheptane substituted oxa prostaglandin analogs are provided having the structural formula ##STR1## wherein R is OH, ##STR2## (wherein R.sup.3 is lower alkyl, aryl, arylalkyl or lower alkylamino), ##STR3## (wherein R.sup.4 and R.sup.5 are the same or different and can be H, alkyl, aryl or arylalkyl, and R.sup.6 is alkyl or O-alkyl); R.sup.1 is lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl; R.sup.2 is hydrogen or lower alkyl; A is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --; n is 1 to 4, and m is 1 to 8, and including all stereoisomers thereof.
The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4187236 (1980-02-01), Sprague
patent: 4220594 (1980-09-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4254044 (1981-03-01), Sprague
Hall Steven E.
Haslanger Martin F.
Varma Ravi K.
Dentz Bernard I.
E. R. Squibb & Sons Inc.
Jiles Henry R.
Levinson Lawrence S.
Rodney Burton
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