7-Oxabicycloheptane substituted oxa prostaglandin analogs and th

Details 7-Oxabicycloheptane substituted oxa prostaglandin analogs and th 7-Oxabicycloheptane substituted oxa prostaglandin analogs and th

1984-04-27

1985-09-17

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549463, A61K 3134, A61K 31557, C07D30700

Patent

active

045421579

ABSTRACT:
7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane, R.sup.1 is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --, y is 0 to 4, m is 0 to 8, and n is 1 to 4, p is 1 to 12 and q is 0 to 5, and including all stereoisomers thereof.
The compounds are antiinflammatory agents useful, for example, in the treatment of inflammatory diseases and analgesic agents as well as cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4187236 (1980-02-01), Sprague
patent: 4220594 (1980-09-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4254044 (1981-03-01), Sprague

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