7-Oxabicycloheptane prostaglandin intermediates

Details 7-Oxabicycloheptane prostaglandin intermediates 7-Oxabicycloheptane prostaglandin intermediates

1983-05-13

1985-03-05

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30788

Patent

active

045032416

ABSTRACT:
7-Oxabicycloheptane prostaglandin intermediates are provided having the general structure ##STR1## wherein one of R.sup.1 and R.sup.2 is ##STR2## and the other is hydrogen. A method for preparing the above intermediates is also provided. The final products are used in the treatment of thrombolytic disease.

REFERENCES:
patent: 4143054 (1979-03-01), Sprague
Orchin et al., The Vocabulary of Organic Chem., Wiley and Sons, (1980), 122,130,131,144.
Haslanger et al., Synthesis, Oct. 1981, pp. 801-802.
Woodward et al., J.A.C.S., vol. 95(20), (1973), pp. 6853-6855.
Mitra, The Synthesis of Prostaglandins, Wiley, 1977, p. 12.
Sprague et al., Advances in Prostaglandin and Thromboxane Research, vol. 6, pp. 493-496, (1980).

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