Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-11-17
1989-11-28
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549463, A61K 3134, C07D30700
Patent
active
048838110
ABSTRACT:
7-Oxabicycloheptane imino interphenylene substituted prostaglandin analogs are provided having the structural formula ##STR1## wherein n is 1 or 2; m is 1 or 2; R is H, lower alkyl, or alkali metal; and R.sup.1 is --OR.sup.2, ##STR2## where R.sup.2 is lower alkyl, aryl, aralkyl, cycloalkylalkyl, alkanoyl or aroyl; and R.sup.3 is lower alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, --NHaralkyl, --NHalkyl, --NHalkylcycloalkyl or --NHaryl.
These compounds are cardiovascular agents which exhibit thromboxane antagonist activity and thus are useful in the treatment of thrombotic and vasospastic disease.
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patent: 4474804 (1984-10-01), Das et al.
patent: 4522949 (1985-06-01), Das et al.
patent: 4535513 (1985-08-01), Das et al.
Hall Steven E.
Misra Raj N.
Dentz Bernard I.
Lee Mary C.
Rodney Burton
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