7-oxabicycloheptane ethers useful in the treatment of thrombotic

Details 7-oxabicycloheptane ethers useful in the treatment of thrombotic 7-oxabicycloheptane ethers useful in the treatment of thrombotic

1985-04-26

1986-08-26

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549463, A61K 31335, A61K 31557, C07D30700

Patent

active

046083863

ABSTRACT:
7-Oxabicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein X is O or ##STR2## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4187236 (1980-02-01), Sprague
patent: 4220594 (1980-09-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4254044 (1981-03-01), Sprague
patent: 4474803 (1984-10-01), Hall
Hall et al., Chem. Abstracts, vol. 102, 131806q, (1985)-Abstract of Ger. Offen. DE 3,409,124, Sep. 1984.

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