7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analog

Details 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analog 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analog

1979-11-01

1980-10-14

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

26034622, A61K 3134, A61K 31557, C07D30728

Patent

active

042281806

ABSTRACT:
New 7-oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs which have the general formula ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; n is 0 to 4, m is 0 to 4 and x is 0 to 8, are useful as cardiovascular agents.

REFERENCES:
patent: 4112224 (1978-09-01), Bundy
patent: 4143054 (1979-03-01), Sprague
Wlodawer et al., J.A.C.S. 93, 2815-2816 (1971).
Bundy, Tet. Letters 24, 1957-1960 (1975).
Rose et al., Proc. Soc. Exp. Biol. & Med., 153, 209-212 (1976).
Corey et al., J.A.C.S. 98, 6417-6418 (1976).
Hamburg et al., Proc. Nat. Acad. Sci., U.S.A. 70, 899-903 (1973).
Gorman et al., Proc. Nat. Acad. Sci., U.S.A. 74, 4007-4011 (1977).
Eggette et al., J. Chem. Soc. Perkin I, pp. 980-989, (1978).

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