Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-11-05
1987-01-20
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549463, A61K 31557, A61K 3134, C07D30700
Patent
active
046380124
ABSTRACT:
7-Oxabicycloheptane .alpha.-substituted ketone prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; X is halogen, alkanoyloxy or hydroxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 is H or lower alkyl; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, amino, alkylamino, or arylamino.
The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
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Dentz Bernard I.
E. R. Squibb & Sons Inc.
Jiles Henry R.
Levinson Lawrence S.
Rodney Burton
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