7-Oxabicyclo(2.2.1)heptane hydroxamic acid derivatives useful as

Details 7-Oxabicyclo(2.2.1)heptane hydroxamic acid derivatives useful as 7-Oxabicyclo(2.2.1)heptane hydroxamic acid derivatives useful as

1986-08-26

1987-06-09

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549463, A61K 3134, A61K 31557, C07D30700

Patent

active

046720758

ABSTRACT:
7-Oxabicyclo(2.2.1)heptane hydroxamic acid derivatives are disclosed having the general formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, aryl, aralkyl or alkenyl; R.sub.2 is hydrogen, lower alkyl, alkanoyl or aroyl; R.sub.3 is lower alkyl, alkenyl or alkynyl; A is --CH.sub.2 --CH.dbd.CH-- or a single bond; and n is an integer from 0 to 9, with the proviso that when A is a single bond, n is an integer from 1 to 9; and including all stereoisomers and pharmaceutically acceptable salts thereof.
These new compounds have been found to simultaneously inhibit the arachidonic acid enzymes cyclooxygenase and 5-lipoxygenase and are therefore useful as antiinflammatory, antiasthma and antipsoriatic agents.

REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4254044 (1981-03-01), Sprague
patent: 4497827 (1985-02-01), Nelson
patent: 4582854 (1986-04-01), Hall et al.
patent: 4604407 (1986-08-01), Haslanger et al.

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