Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-08-26
1987-11-17
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549463, A61K 31557, C07D30700
Patent
active
047074949
ABSTRACT:
7-Oxabicyclo(2.2.1)heptane analogs are disclosed having the general formula ##STR1## wherein R.sub.1 is lower alkyl, alkenyl, substituted alkenyl or alkynyl; R.sub.2 is lower alkyl, alkenyl or alkynyl; A is --CH.sub.2 --CH.dbd.CH-- or a single bond; X is --CH.sub.2, --CH(CH.sub.3) or --C(CH.sub.3).sub.2 ; n is an integer from 0 to 9, with the proviso that when A is a single bond, n is an integer from 1 to 9; including all stereoisomers.
These new compounds have been found to be inhibitors of arachidonic acid cyclooxygenase and are therefore useful as antiinflammatory antipyretic and analgesic agents.
REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4254044 (1981-03-01), Sprague
patent: 4497827 (1985-02-01), Nelson
patent: 4582854 (1986-04-01), Hall et al.
patent: 4588743 (1986-05-01), Harlanger et al.
Ciosek Carl P.
Gordon Eric M.
Varma Ravi K.
Dentz Bernard I.
E. R. Squibb & Sons Inc.
Furman Jr. Theodore R.
Jiles Henry R.
Levinson Lawrence S.
LandOfFree
7-oxabicyclo(2.2.1)heptane compounds useful in the treatment of does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 7-oxabicyclo(2.2.1)heptane compounds useful in the treatment of , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 7-oxabicyclo(2.2.1)heptane compounds useful in the treatment of will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1450410