7-oxabicyclo(2.2.1)heptane-based derivatives useful as antiinfla

Details 7-oxabicyclo(2.2.1)heptane-based derivatives useful as antiinfla 7-oxabicyclo(2.2.1)heptane-based derivatives useful as antiinfla

1986-09-23

1987-09-22

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549463, A61K 31557, C07D30700

Patent

active

046955860

ABSTRACT:
7-Oxabicyclo(2.2.1)heptane-based N-hydroxy-N-alkyl (or aryl) ureas, carbamic acids and carbamothioic acids are disclosed having the general formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, alkenyl, aryl or aralkyl; R.sub.2 is hydrogen, lower alkyl, aralkyl, alkanoyl or aroyl; R.sub.3 is lower alkyl, alkenyl or alkynyl; A is --CH.sub.2 --CH.dbd.CH-- or a single bond; X is oxygen, sulfur or NH; n is an integer from 1 to 8; and all stereoisomers thereof.
These new compounds have been found to simultaneously inhibit the enzymes arachidonic acid cyclooxygenase and arachidonic acid 5-lipoxygenase and are therefore useful as antiinflammatory, antiasthma and antipsoriatic agents.

REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4254044 (1981-03-01), Sprague
patent: 4582854 (1986-04-01), Hall et al.

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