Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-09-23
1987-09-22
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549463, 514863, 514826, A61K 3134, C07D30700
Patent
active
046955852
ABSTRACT:
A compound of the formula ##STR1## wherein R.sub.1 is hydrogen, hydroxy, alkoxy or aryloxy; R.sub.2 is hydrogen, hydroxy, alkoxy or aryloxy; or wherein R.sub.1 and R.sub.2 taken together is an aromatic ring; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is lower alkyl, substituted alkyl, alkenyl or alkynyl; X is amino, alkylamino, alkanoylamino, oxygen or a single bond; A is CH.sub.2 --CH.dbd.CH or a single bond; and n is an integer from 0 to 9, with the proviso that when A is a single bond, n is an integer from 1 to 9 including all stereoisomers thereof.
These new compounds have been found to simultaneously inhibit the arachidonic acid enzymes 5-lipoxygenase and cyclooxygenase and as such are useful, for example, as antiinflammatory agents.
REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4254044 (1981-03-01), Sprague
patent: 4536513 (1985-08-01), Das et al.
patent: 4582854 (1986-04-01), Hall et al.
Gordon Eric M.
Varma Ravi K.
Dentz Bernard I.
E. R. Squibb & Sons Inc.
Furman, Jr. T. R.
Jiles Henry R.
Levinson L. S.
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