7-(or 6-) Substituted-7-(or 6-)acylimino cephalosporin (or penic

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544 21, 424246, 424270, 424271, 2602452R, C07D49902, C07D50114

Patent

active

042962366

ABSTRACT:
A process is provided which yields derivatives of cephalosporins and penicillins. The process starts with 7-aminodecephalosporanic acid or 6-APA and reacts with a carbonyl containing compound to form a Schiff's base (imino) adduct. This latter compound is then treated with a defined reactant yielding a novel Schiff's base adduct having a side chain on the carbon adjacent to the imino-nitrogen. The amino moiety can be regenerated and further reacted to form end compounds which are active against both gram-positive and gram-negative bacteria.

REFERENCES:
patent: 3867379 (1975-02-01), Dolfini et al.
patent: 3954744 (1976-05-01), Dolfini et al.
patent: 4026886 (1977-05-01), Dolfini et al.
patent: 4061851 (1977-12-01), Dolfini et al.
patent: 4071682 (1978-01-01), Dolfini et al.

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