7-N-(Substituted-apramycin antibiotic derivatives and intermedia

Details 7-N-(Substituted-apramycin antibiotic derivatives and intermedia 7-N-(Substituted-apramycin antibiotic derivatives and intermedia

1983-02-17

1984-07-03

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 81, C07H 1522

Patent

active

044580657

ABSTRACT:
Apramycin derivatives substituted at the 7'-amino group with a methyl, ethyl, n-propyl or n-butyl substituent are broad spectrum antibiotics. Also claimed are intermediates in the synthesis of these 7'-N-alkylapramycin derivatives.

REFERENCES:
patent: 4223024 (1980-09-01), McAlpine et al.
patent: 4239752 (1980-12-01), Carney et al.
patent: 4358585 (1982-11-01), Igarashi et al.
patent: 4360665 (1982-11-01), Kirst
patent: 4370475 (1983-01-01), Igarashi et al.
patent: 4379917 (1983-04-01), Kirst
H. A. Kirst et al., Tet. Letters, vol. 22, p. 295, (1981, approximately the first quarter of the year).
J. Davies et al., Antimicrob. Agents Chemother., 14, 69 (1978).
S. O'Connor et al., J. Org. Chem., 41, 2087 (1976).
Y. Abe et al., J. Antibiotics, (Tokyo), 34, 1434 (1981).
Kirst et al., Serial Nos. 304,292 and 304,291, filed 9/21/81, and Serial Nos. 415,122 and 415,207, filed 9/7/82.

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