Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-04-27
1982-11-09
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424251, 544 21, 544 22, 544 25, 544 27, 544 28, C07D50114, A61K 31545
Patent
active
043584470
ABSTRACT:
Disclosed are antibiotic cephalosporins (I) of the formula: ##STR1## Wherein the stylized radical attached to the 7-amino nitrogen of the cephalosporin moiety represents a nitrogen-containing heterocyclic group (mono- or polycyclic); R is, inter alia, hydrogen, alkyl, heterocyclylalkyl, aryl, alkenyl, aralkyl, --NR.sub.2, --OR, COOR, CONR.sub.2 or CN; A is conventionally known in the cephalosporin art; and R.sup.2 is H, or lower alkoxyl. Also disclosed are the pharmaceutically acceptable salt and ester derivatives of I; processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
REFERENCES:
patent: 3821198 (1974-06-01), Lee et al.
patent: 3862181 (1975-01-01), Davis et al.
patent: 3950352 (1976-04-01), Wolfe
patent: 3957764 (1976-05-01), Lund
Arno James A.
Mahon Frank M.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Rizzo Nicholas S.
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