7-N,8-N-Ethylenemitomycin 8-imines

Details 7-N,8-N-Ethylenemitomycin 8-imines 7-N,8-N-Ethylenemitomycin 8-imines

1988-03-29

1989-08-01

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514249, 548422, 544343, 544342, C07D24100, A61K 31495

Patent

active

048533858

ABSTRACT:
7-N,8-N-Ethylenemitomycin 8-imines represented by the formula ##STR1## wherein one of the R.sub.1 and R.sub.2 represents carbamoyloxymethyl and another represents hydrogen or both are combined together to form methylene; R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each independently represent hydrogen or C.sub.1-4 alkyl, or R.sub.3 and R.sub.4 may be combined together to represent --(CH.sub.2).sub.n --, wherein n is 3 or 4; and Y and Z represent hydrogen or methyl, provided that when R.sub.1 represents carbamoyloxymethyl and Y represents methyl, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and Z are not hydrogen simultaneously, has an excellent antitumor activity.

REFERENCES:
patent: 4264504 (1981-04-01), Urakawa et al.
patent: 4374774 (1983-02-01), Kasai et al.
patent: 4395558 (1983-07-01), Kasai et al.
patent: 4617389 (1986-10-01), Remers
Merck Index, 10th Ed. (1983), pp. 890-891, 1097.
J. Med. Chem., 26, 16-20 (1983).
J. Med. Chem., 26, 1453-57 (1983).

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