7-Mercapto(or thio)-benzothiadiazine products

Details 7-Mercapto(or thio)-benzothiadiazine products 7-Mercapto(or thio)-benzothiadiazine products

1974-12-04

1976-04-20

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D28522

Patent

active

039519678

ABSTRACT:
7-Mercapto(or alkyl- or aralkylthio)-1,2,4-benzothiadiazine-1,1-dioxide compounds are described. Products are prepared by reducing a 7-chlorosulfonyl substituent to the 7-mercapto and then, if desired, alkylating or aralkylating to provide 7-thio substituent. Alternatively, a 4-RS-orthanilamide can be cyclized by known procedures to provide a 3-unsubstituted or 3-substituted analog. Products are xanthine oxidase inhibitors.

REFERENCES:
patent: 3351595 (1967-11-01), de Stevens et al.
patent: 3419552 (1968-12-01), Whitehead et al.
patent: 3514454 (1970-05-01), McLamore et al.

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