7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-

Details 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5- 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-

1989-08-24

1991-07-16

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514178, 514181, 514182, 540108, 540110, 552530, 552531, 552533, 552534, 552599, 552600, 552603, 552606, 552610, 552611, A61K 3156, C07J 4300

Patent

active

050325868

ABSTRACT:
Invented are carboxyl and carboxyl alkyl ester substituted 7-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are methods for preparing these compounds.

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patent: 4814324 (1989-03-01), Borris et al.
Hsia and Voight, J. Invest. Dermat. 62:224-227 (1974).
Robaire et al., J. Steroid Biochem. 8:307-310 (1977).
Blohm, T. R., et al., Biochem. Biophys. Res. Comm. 95:273-280 (1980).
Liang, T., et al., J. Steroid Biochm. 19:385-390 (1983).
Petrow, V., et al., Steroids 38:121-140 (1981).
Brooks et al., Steroids: 47:1-19 (Jan. 1986).

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