7-hydroxy coumarins having substitutions in the 4 position

Details 7-hydroxy coumarins having substitutions in the 4 position 7-hydroxy coumarins having substitutions in the 4 position

1991-05-21

1993-05-04

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549214, C07D31116

Patent

active

052083500

ABSTRACT:
This invention relates to fluorescent 7-hydroxy coumarin compounds with substitutions in the 4 position having a length greater than one carbon atom. The compounds thus are related to 4-methylumbelliferone (7-hydroxy-4-methyl coumarin, or 4-MU), the detectable label used in the IM.sub.x .RTM. instrument assays (Abbott Laboratories, Abbott Park, Ill.). The substitutions in the 4 position are branched and include functional groups for coupling to biological molecules.

REFERENCES:
patent: 4618622 (1986-10-01), Schlecker et al.
Kato et al., CA 91:74247m.

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