Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1974-08-13
1976-08-10
Rizzo, Nicholas S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424246, C07D50160
Patent
active
039741532
ABSTRACT:
Cephalosporin antibiotics in which the 7.beta.-acylamido group has the structure ##EQU1## where R.sup.1 is a furyl, thienyl or phenyl group and R.sup.2 is a C.sub.1 -C.sub.4 alkyl, C.sub.3 C.sub.7 cycloalkyl or phenyl group and in which the 3-position substituent is a carbamoyloxymethyl group possess a particularly valuable combination of properties, exhibiting high antibacterial activity against a broad range of gram positive and gram negative organisms, particularly high stability to .beta.-lactamases produced by various organisms, and stability in vivo. The compounds are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer. Particularly important compounds of this type are (6R,7R)-3-carbamoyloxymethyl -7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acid (syn isomer) and its non-toxic derivatives, e.g. the sodium salt.
REFERENCES:
patent: 3484437 (1969-12-01), Urech et al.
patent: 3546219 (1970-12-01), Long et al.
patent: 3573294 (1971-03-01), Long et al.
patent: 3706746 (1972-12-01), Bosshardt et al.
Bradshaw Janice
Cook Martin Christopher
Gregory Gordon Ian
Glaxo Laboratories Limited
Rizzo Nicholas S.
Tovar Jose
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