7-hexanoyltaxol and methods for preparing the same

Details 7-hexanoyltaxol and methods for preparing the same 7-hexanoyltaxol and methods for preparing the same

1998-04-10

2000-10-24

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

061369888

ABSTRACT:
An antitumor compound of formula (5) ##STR1## and also provided by the present invention is a method of preparing a compound of formula (5) whereby diesterification of the alcohol groups located at the 2' and 7 positions of paclitaxel is followed by the hydrolysis of the 2' hexanoate group resulting in 7-hexanoyltaxol.

REFERENCES:
patent: 5227400 (1993-07-01), Holton et al.
patent: 5243045 (1993-09-01), Holton et al.
patent: 5250683 (1993-10-01), Holton et al.
patent: 5283253 (1994-02-01), Holton et al.
patent: 5284864 (1994-02-01), Holton et al.
patent: 5284865 (1994-02-01), Holton et al.
patent: 5352806 (1994-10-01), Gunawardana et al.
patent: 5380751 (1995-01-01), Chen et al.
patent: 5422364 (1995-06-01), Nicolaou et al.
patent: 5721268 (1998-02-01), Holton et al.
"Structure--Activity Relationship studies of New Taxanes As Reversal Agents for Multi-Drug Resistance in Cancer Cells," Iwao Ojima, et al., MEDI, Apr. 2, 1998.

Affiliated with

Also associated with

Rating

7-hexanoyltaxol and methods for preparing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 7-hexanoyltaxol and methods for preparing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 7-hexanoyltaxol and methods for preparing the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1965416