7[(Furanyl-2-acetamido)-2-acetamido]cephalosporin derivatives

Details 7[(Furanyl-2-acetamido)-2-acetamido]cephalosporin derivatives 7[(Furanyl-2-acetamido)-2-acetamido]cephalosporin derivatives

1978-11-06

1980-08-05

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 22, 544 28, A61K 31545, C07D50134

Patent

active

042162157

ABSTRACT:
A series of novel 7-(D-.alpha.-acylaminoarylacetamido)-.DELTA..sup.3 -cephem derivatives have been prepared wherein the acyl moiety contains an epoxy group immediately adjacent to the carbonyl carbon atom. These compounds are useful as antibacterial agents for the treatment of diseases caused by Gram-negative and Gram-positive bacteria. Preferred members include 7-[D-.alpha.-(cis-2-carboxyoxiran-3-carboxamido)phenylacetamido]-3-(1-meth yl-1,2,3,4-tetrazol-5-ylthiomethyl)-.DELTA..sup.3 -cephem-4-carboxylic acid and 7-[D-.alpha.-(cis-2-carboxyoxiran-3-carboxamido)phenylacetamido]cephalospo ranic acid. Alternate methods of preparation are provided for these compounds and the principal synthetic route is described in detail.

REFERENCES:
patent: 3988325 (1976-10-01), Spitzer et al.
patent: 4041161 (1977-08-01), Kocsis et al.
patent: 4101661 (1978-07-01), Kalten

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