7-diphenylmethylenebicycloheptane or 7-diphenylmethylenebicylcoh

Details 7-diphenylmethylenebicycloheptane or 7-diphenylmethylenebicylcoh 7-diphenylmethylenebicycloheptane or 7-diphenylmethylenebicylcoh

1988-09-21

1992-08-25

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142378, 5142395, 514255, 514511, 514569, 514617, 514619, 514622, 514640, 514648, 514676, 514681, 514717, 514719, 514724, 544165, 544174, 544176, 544178, 544391, 544396, 564163, 564172, 564180, 564315, 564265, C07D295192, A61K 31535

Patent

active

051419378

ABSTRACT:
Pharmaceutical products containing a 7-diphenylmethylenebicycloheptane or 7-diphenylmethylenebicycloheptene derivative of the formula I ##STR1## in which A, B, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the stated meanings, or a physiologically tolerated acid addition salt of these compounds, and the use thereof as hypolipidemics are described. In addition, new 7-diphenylmethylenebicycloheptane and -heptene derivatives of the formula Ia ##STR2## in which A, B, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the stated meanings, and the physiologically tolerated acid addition salts thereof, as well as processes for the preparation thereof, are described.

REFERENCES:
patent: 4550186 (1985-10-01), McPhail et al.
patent: 4647575 (1987-03-01), Siegel et al.
Yates, P. & Kronis, J., "Aliphatic diazo compounds. XIV. The synthesis of 7-substituted 3-diazo-2-norbornanones", Dec. 14, 1983, Can. J. Chem., vol. 62, 1984.
Synthesis, International Journal of Methods in Synthetic Organic Chemistry, No. 8, Aug. 1985, pp. 798-801.
Annalen der Chemie, 566, 27 (1950) (including pages 27-59).
J. Med. Pharm. Chem., vol. 5, No. 5 (1962), pp. 883-896.

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