Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1977-04-25
1978-08-15
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
544 23, 544 28, 544 29, 544 30, C07D50132, C07D50134
Patent
active
041074327
ABSTRACT:
New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to produce cephalosporins containing a different acylamido moiety. Thus, the aminoadipoyl group of cephalosporins produced by fermentation is replaced by a different acyl group by the process of the present invention. The cephalosporins produced are antibiotics having enhanced activity against gram-negative and gram-positive pathogens.
REFERENCES:
patent: 3859282 (1975-01-01), Cheng et al.
patent: 3926954 (1975-12-01), Kiesewetter et al.
Karady et al., J. Am. Chem. Soc. 94(4), pp. 1410-1411, 2/72.
Abe et al., Chemical Abstracts, vol. 78, 27,925c(1973).
Cama Lovji D.
Christensen Burton G.
Karady Sandor
Sletzinger Meyer
Daus Donald G.
Levitt Julian S.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Rivers Diana G.
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