Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1975-04-07
1977-11-15
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
424246, 544 22, 544 28, 544 30, 544 16, 544 26, C07D50146, C07D50144, C07D50142, C07D50140
Patent
active
040586618
ABSTRACT:
New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to produce cephalosporins containing a different acylamido moiety. Thus, the aminoadipoyl group of cephalosporins produced by fermentation is replaced by a different acyl group by the process of the present invention. The cephalosporins produced are antibiotics having enhanced activity against gram-negative and gram-positive pathogens.
REFERENCES:
patent: 3897424 (1975-07-01), Koppel et al.
patent: 3910902 (1975-10-01), Dolfini et al.
patent: 3926954 (1975-12-01), Kiesewetter et al.
Cama Lovji D.
Christensen Burton G.
Karady Sandor
Sletzinger Meyer
Levitt Julian S.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Rivers Diana G.
Rizzo Nicholas S.
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