7-deazapurine derivatives useful as antitumor agents

Details 7-deazapurine derivatives useful as antitumor agents 7-deazapurine derivatives useful as antitumor agents

1985-05-01

1987-03-17

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544117, 544229, C07D47102

Patent

active

046508686

ABSTRACT:
7-Deazapurine derivatives of the formula: ##STR1## wherein R.sup.1 is phenyl which has, at the ortho position and/or para position as substituents, at least one group represented by the formula --O--R.sup.3, --S--R.sup.4 or ##STR2## (wherein R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or different and each is hydrogen or an alkyl or phenyl group which may be substituted, whereby R.sup.5 and R.sup.6, together with the adjacent nitrogen atom, may form a cyclic amino group which may be substituted, and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each may represent a protective group), and may have a group or groups with a molecular weight of up to about 200 as a substituent at any position other than those having the said substituents introduced; R.sup.2 is an amino group which may be protected, or its salt, have a potent antitumor activity, and hence the compounds are useful as an antitumor agent.

REFERENCES:
patent: 4435569 (1984-03-01), Nishimura et al.
patent: 4435570 (1984-03-01), Nishimura et al.
patent: 4571423 (1986-02-01), Nomura et al.
patent: 4595530 (1986-06-01), Nishimura et al.

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