7-deaza-2'-deoxyguanosine nucleotides

Details 7-deaza-2'-deoxyguanosine nucleotides 7-deaza-2'-deoxyguanosine nucleotides

1986-08-13

1989-02-14

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, 536 26, 536 27, 536 29, C07H 1914, C12P 100

Patent

active

048047481

ABSTRACT:
The present invention provides 7-deaza-2'-deoxy-guanosine nucleotides of the general formula: ##STR1## wherein R is a --PO.sub.3 H.sub.2, --P.sub.2 O.sub.6 H.sub.3 or --P.sub.3 O.sub.9 H.sub.4 residue or an alkali metal, alkaline earth metal or ammonium salt of the phosphate groups. The present invention also provides processes for the preparation of these nucleotides and is also concerned with the use thereof in the sequencing of DNA.

REFERENCES:
patent: 3321463 (1967-05-01), Moffatt
patent: 3337530 (1967-08-01), Hanze
Winkeler, H-D. Seela F., J. Org. Chem., vol. 48, pp. 3119-3122, 1983.
Barr et al, Bio Techniques, vol. 4(5), pp. 428-432, 1986.
Mizusawa et al., Nucleic Acids Research, vol. 14(3) pp. 1319-1324, 1986.

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