7-(D-.alpha.-Hydroxy-2-arylacetamido)-3-(2-carboxyalkyl-2,3-dihy

Details 7-(D-.alpha.-Hydroxy-2-arylacetamido)-3-(2-carboxyalkyl-2,3-dihy 7-(D-.alpha.-Hydroxy-2-arylacetamido)-3-(2-carboxyalkyl-2,3-dihy

1977-03-16

1978-09-05

Rollins, Alton D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544236, 424245, 424246, 544 4, 544 23, 544 27, 560226, 560254, C07D50154, C07D50156, C07D51900

Patent

active

041122283

ABSTRACT:
7-(D-.alpha.-Hydroxy-2-arylacetamido)-3-(2-carboxyalkyl-2,3-dihydro-s-triaz olo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids and derivatives containing blocking groups on the .alpha.-hydroxy group and their nontoxic, pharmaceutically acceptable salts are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and in animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria. A preferred compound is 7-(D-mandelamido)-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin -3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acid.

REFERENCES:
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patent: 3813391 (1974-05-01), Naito et al.
patent: 3814775 (1974-06-01), Naito et al.
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patent: 3883520 (1975-05-01), De Marinis
patent: 3907786 (1975-09-01), Naito et al.
patent: 3928336 (1975-12-01), Essery et al.
patent: 3931160 (1976-01-01), Dunn
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Farmdoc Abstract 22850w.
Farmdoc Abstract 18330x.

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