7-D-(.alpha.-acylamino-arylacetamido)-cephalosporanic acid deriv

Details 7-D-(.alpha.-acylamino-arylacetamido)-cephalosporanic acid deriv 7-D-(.alpha.-acylamino-arylacetamido)-cephalosporanic acid deriv

1975-11-26

1977-02-01

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260243C, 260326R, 260475SC, 260 4PS, C07D50124, C07D50132

Patent

active

040062309

ABSTRACT:
Novel antibacterial agents; namely, 7-(.alpha.-acylamino-arylacetamido)-cephalosporanic acid derivatives having the formula: ##STR1## wherein R.sup.1 is thienyl, 2-furyl, phenyl, substituted thienyl or substituted phenyl; R is hydroxyl; R.sup.2 is hydrogen, hydroxy, acetoxy, carbamoyloxy, N-pyridyl, azido or heterocyclic thio group; R and R.sup.2 when taken together represent an oxygen atom; R.sup.3 is sulpho or COOR.sup.4.sup.' wherein R.sup.4.sup.' is hydrogen or R.sup.4 wherein R.sup.4 is lower alkyl, 5-indanyl, naphthyl, phenyl, or substituted phenyl, CONR.sup.5 R.sup.6, wherein each of R.sup.5 and R.sup.6 is hydrogen, lower alkyl or cycloalkyl; or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are attached form a saturated heterocyclic group; X is oxygen or sulphur, a direct link, carbonyl, methylene, hydroxymethylene, sulphinyl, sulphonyl or an imino group of the formula --NR.sup.7 --, wherein R.sup.7 is hydrogen, lower alkyl, lower alkenyl, or benzyl; and each of alk.sup.1 and alk.sup.2 is a divalent saturated aliphatic hydrocarbon group containing from 1 to 3 carbon atoms; the pharmaceutically acceptable salts thereof, and methods for their preparation.

REFERENCES:
patent: 3341532 (1967-09-01), Lewis et al.
Heusler et al., "Chemical Abstracts," 23-12-71, vol. 76, p. 460, Abst. No. 99691e.

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