7-chloroquinaldine synthesis

Details 7-chloroquinaldine synthesis 7-chloroquinaldine synthesis

1991-10-17

1992-06-30

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21518

Patent

active

051264560

ABSTRACT:
An improved process is described which utilizes tetrachloro-1,4(or 1,2)-quinone as an oxidant in the Doebner-Miller synthesis of 7-chloroquinaldine, a starting material in the preparation of leukotriene antagonists. The process improves yield and eliminates the need of forming a ZnCl.sub.2 complex to isolate the end product.

REFERENCES:
patent: 2507146 (1950-05-01), Dickey
W. P. Utermohlen, Jr., J. Org. Chem., 1943, 8, 544.
C. M. Leir, J. Org. Chem., 1977, 42, 911.
A. M. Speivey et al., J. Chem., Soc., 1949, 2656.

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