7-carboxymethyloxy-3′,4′,5-trimethoxy flavone...

Details 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone... 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone...

2008-05-13

2008-05-13

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S403000

Reexamination Certificate

active

10564128

ABSTRACT:
The present invention relates to 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone.monohydrate which is a non hygroscopic product suitable for the preparation of metered dose of 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone having protective activity for gastrointestinal tract including the colon, and a preparation method and uses thereof. 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone.monohydrate of the present invention has advantages such as mucus protecting activity for gastrointestinal tract including the colon, convenience for handling and storage under ordinary humidity owing to its non-hygroscopicity, and ability to contain an active compound consistently for the formulation production of a medicine. In addition, the preparation method of 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone.monohydrate of the present invention reduces long steps of total synthesis and requires mild conditions for the production of a compound because autoclave condition is not necessary for methylation in this case, and makes mass-production possible without any purification process such as recrystallization or column chromatography.

REFERENCES:
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patent: 99-41205 (2001-04-01), None
patent: WO 98/04541 (1998-02-01), None
Mizui, Takuji, et al., Effect of Polyamines on Acidified . . . , Japan, J. Pharmacol. 33, pp. 939-945, (1983).
Shibata, Yoshimi, et al., Endoscopic Scoring System for Experimental . . . , Dig. Endosc. vol. 5, pp. 13-17, 1993.
Wallace, John L., Release of Platelet-Activating Factor (PAF) and Accelerated . . . , Can. J. Physiol. Pharmacol. vol. 66, pp. 422-425.
Moyana, Terence N., et al., Carrageenan-Induced Intestinal . . . , Ann. of Clinical and Laboratory Science, vol. 20, No. 6.

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