7-Carboxymethoxyphenylacetamido-3-cephem derivatives and antibac

Details 7-Carboxymethoxyphenylacetamido-3-cephem derivatives and antibac 7-Carboxymethoxyphenylacetamido-3-cephem derivatives and antibac

1983-10-20

1985-10-08

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 25, 544 27, 544 28, 514338, 514434, C07D50100, C07D50114, A61K 3154

Patent

active

045461767

ABSTRACT:
7-Carboxymethoxyphenylacetamido-3-cephem derivatives represented by the formula ##STR1## wherein R.sub.1 means hydroxy, C.sub.1 -C.sub.4 alkanoyloxy or C.sub.1 -C.sub.4 alkoxycarbonyloxy, R.sub.2 is hydrogen or methoxy, R.sub.3 denotes C.sub.1 -C.sub.4 alkanoyloxy, substituted or unsubstituted nitrogen-containing heterocyclic-thio or substituted or unsubstituted pyridinium with a proviso that, when R.sub.3 denotes the substituted or unsubstituted pyridinium, R.sub.3 forms an intramolecular salt with the carboxy at the 4-position of the cephem nucleus, and A is a group of the following formula: ##STR2## in which R.sub.4 and R.sub.5 are individually hydrogen or C.sub.1 -C.sub.4 alkyl, and their pharmaceutically acceptable salts, exhibit excellent anti-bacterial activities against Gram-negative bacteria, particularly, Pseud. aeruginosa, Kleb. pneumoniae, Ser. marcescens and the like.

REFERENCES:
patent: 4015000 (1977-03-01), Kocsis et al.
patent: 4338439 (1982-07-01), Herron et al.
patent: 4344944 (1982-08-01), Machida et al.

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