7-bromo-beta-carboline compound and method for producing same

Details 7-bromo-beta-carboline compound and method for producing same 7-bromo-beta-carboline compound and method for producing same

1987-12-21

1990-01-16

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 86, 546 87, C07D47104

Patent

active

048944572

ABSTRACT:
A 7-bromo-.beta.-carboline compound of the formula (I): ##STR1## wherein R.sup.1 =H or C.sub.1 -C.sub.5 alkyl and R.sup.2 =C.sub.1 -C.sub.5 alkyl or benzyl, is produced by reacting a .beta.-carboline compound of the formula (II): ##STR2## wherein R.sup.1 and R.sup.2 are as defined above and R.sup.3 =H, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy or benzyloxy, with a brominating agent in an organic solvent in the presence of an alkalic and then hydrolyzing the resultant procursory 7-bromo-.beta.-carboline compound of the formula (III): ##STR3## is a solvent in the presence of a mineral acid.

REFERENCES:
Journal of the American Chemical Society, vol. 109, No. 11, 1987, Kenneth L. Rinehart: "Eudistomins A Q, Beta-Carbolines from the Antiviral Caribbean Tunicate Eudistoma Olivaceum", pp. 3378-3387; p. 3384, line 59, p. 3380, Scheme II.

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