7-.beta.-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compound

Details 7-.beta.-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compound 7-.beta.-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compound

1982-06-24

1984-03-27

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1916

Patent

active

044396040

ABSTRACT:
Hydroxy, amino and sulfhydryl derivatives of 7-.beta.-D-arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine, their corresponding esters and non-toxic pharmaceutically acceptable salts are produced by arabinofuranosylation of the requisite heterocycles with 2,3,5-tri-O-benzyl-.alpha.-D-arabinofuranosyl halide and further reaction to obtain the desired compounds. These water soluble compounds are resistant to adenosine deaminase and exhibit antiviral activity.

REFERENCES:
patent: 3501456 (1970-03-01), Shen et al.
patent: 3992531 (1976-11-01), Prasad et al.
patent: 4352795 (1982-10-01), Cook
Tolman et al., "Pyrrolopyrimidine Nucleosides. VI", vol. 7, pp. 799-806, Aug. 1970.

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