7.beta.-Arylalkyl-7.alpha.-methyl-6-oxo or 6.alpha.-hydroxy-3-me

Details 7.beta.-Arylalkyl-7.alpha.-methyl-6-oxo or 6.alpha.-hydroxy-3-me 7.beta.-Arylalkyl-7.alpha.-methyl-6-oxo or 6.alpha.-hydroxy-3-me

1982-09-09

1984-04-03

Daus, David G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424260, 546 39, 546 45, C07D48902, A61K 31485

Patent

active

044409320

ABSTRACT:
Disclosed are 7.beta.-arylalkyl-7.alpha.-methyl-6-oxo or 6.alpha.-hydroxy-3-methoxy or 3-hydroxy-4,5.alpha.-epoxy-17-methyl or 17-cycloalkylmethyl-morphinans of the formula: ##STR1## wherein R is H or methyl, X is oxo or .alpha.-hydroxy, n is 2 to 4 and R.sub.1 is methyl, cyclopropylmethyl or cyclobutylmethyl. These compounds are useful as strong analgesics.

REFERENCES:
patent: 2178010 (1939-10-01), Small et al.
patent: 4275205 (1981-06-01), Kotick et al.
patent: 4347361 (1982-08-01), Quick et al.
Kotick et al., J. Med. Chem., 24(12), pp. 1445-1450, (1981).
Stork, "The Alkaloids", vol. VI, Manske, ed., Academic Press, N.Y., (1960), p. 226.
Quick et al., J. Med. Chem., 25(8), pp. 983-986, (1982).
Leland et al., J. Org. Chem., 48(11), pp. 1813-1819, (1983).
Kotick et al., J. Med. Chem., 26(7), pp. 1050-1056, (1983).

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