7.beta.-Arylalkyl-6.alpha., 7 .alpha.-oxymethylene-3-methoxy or

Details 7.beta.-Arylalkyl-6.alpha., 7 .alpha.-oxymethylene-3-methoxy or 7.beta.-Arylalkyl-6.alpha., 7 .alpha.-oxymethylene-3-methoxy or

1982-07-30

1984-04-17

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424260, 546 44, C07D48902, A61K 31485

Patent

active

044436050

ABSTRACT:
Disclosed are 7.beta.-arylalkyl substituted morphinan compounds characterized by the formula: ##STR1## In the above formula, R is H or methyl, R.sub.1 is methyl, cyclopropylmethyl or cyclobutylmethyl and n is 2 to 5.

REFERENCES:
patent: 3432486 (1969-05-01), Minato
patent: 4275205 (1981-01-01), Kotick et al.
Kotick, et al., J. Med. Chem. 24(12), p. 1445-1450 (1981).
Leland, et al., J. Org. Chem., 48(11), pp. 1813-1819 (1983).
J. Med. Chem., 26 (7), pp. 1050-1056 (1983), Kotick, et al.
Leland, et al., J. Med. Chem., vol. 24, No. 6, pp. 717-721 (06/81).

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