Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1982-09-09
1984-04-03
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
424260, 546 39, 546 45, C07D48902, A61K 31485
Patent
active
044409311
ABSTRACT:
Disclosed are 7.beta.-alkyl or arylalkyl-3-methoxy or hydroxy-4,5.alpha.-epoxy-6.beta.-hydroxy-7.alpha.-hydroxymethyl-17-methyl or cycloalkylmethylmorphinans of the formula: ##STR1## In the above formula, R is H or methyl, R.sub.1 is methyl, cyclopropylmethyl or cyclobutylmethyl, n is 2 to 4 and Y is H or phenyl. These compounds are useful as narcotic analgesics.
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Kotick, et al., J. Med. Chem., 26(7), pp. 1050-1056, (1983).
Kotick Michael P.
Leland David L.
Polazzi Joseph O.
Daus Donald G.
Jeffers Jerome L.
Miles Laboratories Inc.
Rivers Diana G.
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