7-.beta.-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic ac

Details 7-.beta.-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic ac 7-.beta.-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic ac

1973-11-08

1976-06-29

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50120

Patent

active

039667170

ABSTRACT:
The invention provides novel antibiotic compounds comprising 7.beta.-acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and non-toxic derivatives thereof wherein the acylamido group has the structure ##EQU1## IN WHICH R is a carbocyclic or heterocyclic aryl group and R.sup.a is a lower alkyl, cycloalkyl or phenyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various organisms and stability in the presence of human serum. The invention is also concerned with the administration of the compounds.

REFERENCES:
patent: 3546219 (1970-12-01), Long et al.
patent: 3573294 (1971-03-01), Long et al.

Affiliated with

Also associated with

Rating

7-.beta.-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic ac does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 7-.beta.-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic ac, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 7-.beta.-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic ac will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1277045