7.beta.-[2-Etherified oximino-2-(phenyl or naphthylacetamido)]ce

Details 7.beta.-[2-Etherified oximino-2-(phenyl or naphthylacetamido)]ce 7.beta.-[2-Etherified oximino-2-(phenyl or naphthylacetamido)]ce

1977-01-26

1978-05-23

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424246, C07D50120

Patent

active

040912094

ABSTRACT:
The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is an etherifying monovalent organic group linked to the oxygen atom through a carbon atom. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

REFERENCES:
patent: 3966717 (1976-06-01), Cook et al.
patent: 3971778 (1976-07-01), Cook et al.
patent: 3974153 (1976-08-01), Cook et al.
patent: 4007174 (1977-02-01), Laundon
patent: 4024137 (1977-05-01), Cook et al.
patent: 4033950 (1977-07-01), Cook et al.

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