7.beta.-[[[(2-Cyanomethyl)amino]-1,2-dioxoethyl]amino]acyl cepha

Details 7.beta.-[[[(2-Cyanomethyl)amino]-1,2-dioxoethyl]amino]acyl cepha 7.beta.-[[[(2-Cyanomethyl)amino]-1,2-dioxoethyl]amino]acyl cepha

1977-04-21

1978-06-20

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

2604654, 544 21, 544 27, 544 4, C07D50136

Patent

active

040963306

ABSTRACT:
7.beta.-[[[(2-Cyanomethyl)amino]-1,2-dioxoethyl]amino]-acyl cephalosporins which have the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, tri(lower alkyl)stannyl, trihaloethyl or a salt forming ion; R.sub.1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl, phenyl, phenyl-lower alkyl, substituted phenyl or certain heterocyclic groups; R.sub.2 is hydrogen or methoxy; R.sub.3 is hydrogen, lower alkyl, phenyl-lower alkyl or cycloalkyl; R.sub.4 and R.sub.5 each is hydrogen or lower alkyl; and X is hydrogen, lower alkanoyloxy, carbamoyloxy, lower alkoxy, lower alkylthio ##STR2## or certain heterothio groups, are useful as antibacterial agents.

REFERENCES:
patent: 3573294 (1971-03-01), Long et al.
patent: 3997533 (1976-12-01), Kabbe et al.
patent: 4028354 (1977-06-01), Breuer et al.

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