7.beta.-[2-Aryl-2-(etherified oximino)acetamido]-3-N-substituted

Details 7.beta.-[2-Aryl-2-(etherified oximino)acetamido]-3-N-substituted 7.beta.-[2-Aryl-2-(etherified oximino)acetamido]-3-N-substituted

1976-12-10

1978-10-24

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 16, C07D50120

Patent

active

041222598

ABSTRACT:
Cephalosporin antibiotics in which the 7.beta.-acylamido group is syn 2-aryl-2-(etherified imino) acetamido and in which the 3-position substituent is an alkyl-, alkenyl-etc. substituted carbamoyloxymethyl group exhibit high antibacterial activity against a broad range of gram positive and gram negative organisms, particularly high stability to .beta.-lactamases produced by various organisms, and stability in vivo. The compounds are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer.

REFERENCES:
patent: 3974153 (1976-08-01), Cook et al.

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