7.beta.-[(2-Amino-1,2-dioxoethyl)amino]acyl cephalosporins

Details 7.beta.-[(2-Amino-1,2-dioxoethyl)amino]acyl cephalosporins 7.beta.-[(2-Amino-1,2-dioxoethyl)amino]acyl cephalosporins

1977-03-10

1978-09-12

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

562450, 562507, 562561, 544 19, 544 21, 544 27, 544 30, 544 4, 424246, 560 41, 560125, 560171, 560142, 2603322R, 2603474, 560169, C07D50136

Patent

active

041139437

ABSTRACT:
7.beta.-[(2-Amino-1,2-dioxoethyl)amino]acyl cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl or a salt forming ion; R.sub.1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl, phenyl, phenyl-lower alkyl, substituted phenyl or certain heterocyclic groups; R.sub.2 is hydrogen or methoxy; R.sub.3 is hydrogen, lower alkyl or cycloalkyl; and X is hydrogen, lower alkanoyloxy, carbamoyloxy, lower alkoxy, lower alkylthio ##STR2## or certain heterothio groups, are useful as antibacterial agents.

REFERENCES:
patent: 3573294 (1971-03-01), Long et al.
patent: 4028354 (1977-06-01), Breuer et al.

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