7.beta.-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins

Details 7.beta.-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins 7.beta.-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins

1978-05-30

1979-10-02

Wheeler, David

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 4, 544 21, 544 22, 544 24, 544 25, 544 26, 544 28, 544 30, C07D50136, C07D50134, C07D50146, C07D50122

Patent

active

041699475

ABSTRACT:
7.beta.-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl or a salt forming ion; R.sub.1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl, phenyl, phenyl-lower alkyl, substituted phenyl or certain heterocyclic groups; R.sub.2 is hydrogen or methoxy; R.sub.3 is hydrogen, lower alkyl or phenyl-lower alkyl; R.sub.4 is lower alkyl, cycloalkyl, phenyl, substituted phenyl or certain heterocyclic groups; and X is hydrogen, lower alkanoyloxy, carbamoyloxy, lower alkoxy, lower alkylthio, ##STR2## or certain heterothio groups, are useful as antibacterial agents.

REFERENCES:
patent: 4096330 (1978-06-01), Treuner et al.
patent: 4113943 (1978-09-01), Treuner et al.

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