7-azaindoles, pharmaceutical compositions and their...

Details 7-azaindoles, pharmaceutical compositions and their... 7-azaindoles, pharmaceutical compositions and their...

2007-03-05

2009-06-02

Richter, Johann R (Department: 1616)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S300000

Reexamination Certificate

active

07541464

ABSTRACT:
The present invention relates generally to compounds and compositions for the treatment of metabolic diseases and specifically, the present invention relates to compounds that therapeutically modulation and control lipid and/or carbohydrate metabolism and are thus suitable for the prevention and/or treatment of diseases such as type 2 diabetes, atherosclerosis, and the diverse manifestations thereof. The present invention relates to 7-azaindoles, their physiologically acceptable salts and functional derivatives thereof that exhibit a high degree of peroxisome proliferator-activated receptors (PPAR) agonist activity. Compounds of the present invention are described by formula I:in which the R-groups are herein defined, together with their pharmaceutically acceptable salts, therapeutic methods for their use and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved.

REFERENCES:
patent: 1445258 (2004-08-01), None
patent: WO 2004/074284 (2004-09-01), None
patent: WO 2004074284 (2004-09-01), None

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