7-azaindoles and the use thereof as therapeutic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S113000

Reexamination Certificate

active

10826136

ABSTRACT:
The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.

REFERENCES:
patent: 6008231 (1999-12-01), Lebaut et al.
patent: 6251923 (2001-06-01), Hofgen et al.
patent: 6344467 (2002-02-01), Lebaut et al.
patent: 2002/0111351 (2002-08-01), Hofgen et al.
patent: 2002/0115651 (2002-08-01), Hofgen et al.
patent: 2002/0119971 (2002-08-01), Hofgen et al.
patent: 2002/0137745 (2002-09-01), Hofgen et al.
patent: 2002/0161025 (2002-10-01), Lebauf et al.
patent: 2003/0134876 (2003-07-01), Hofgen et al.
patent: 2003/0207892 (2003-11-01), Lebauf et al.
patent: 2004/0106641 (2004-06-01), Hofgen et al.
patent: 748403 (2002-06-01), None
patent: 198 18 964 (1999-11-01), None
patent: WO-96/11929 (1996-04-01), None
patent: WO-98/09946 (1998-03-01), None
patent: WO-02/34747 (2002-05-01), None
Armin Hatzelmann & Christian Schudt, Anti-Inflammatory and Immunomodulatory Potential of the Novel PDE4 Inhibitor Roflumilast in vitro, The Journal of Pharmacology and Experimental Therapeutics, 297:267-279, 2001.
Milano, Active Drug Metabolites, Clinical Pharmacokinetics 10:216-227 (1985).
Hulme, et al. “Orally Active Indole N-Oxide PDE4 Inhibitors”, Bioorganic and Medicinal Chemistry Letters (1998). 8, 3053-3058).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

7-azaindoles and the use thereof as therapeutic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 7-azaindoles and the use thereof as therapeutic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 7-azaindoles and the use thereof as therapeutic agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3808467

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.