Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-05-01
2007-05-01
Davis, Zinna N. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S113000
Reexamination Certificate
active
10826136
ABSTRACT:
The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
REFERENCES:
patent: 6008231 (1999-12-01), Lebaut et al.
patent: 6251923 (2001-06-01), Hofgen et al.
patent: 6344467 (2002-02-01), Lebaut et al.
patent: 2002/0111351 (2002-08-01), Hofgen et al.
patent: 2002/0115651 (2002-08-01), Hofgen et al.
patent: 2002/0119971 (2002-08-01), Hofgen et al.
patent: 2002/0137745 (2002-09-01), Hofgen et al.
patent: 2002/0161025 (2002-10-01), Lebauf et al.
patent: 2003/0134876 (2003-07-01), Hofgen et al.
patent: 2003/0207892 (2003-11-01), Lebauf et al.
patent: 2004/0106641 (2004-06-01), Hofgen et al.
patent: 748403 (2002-06-01), None
patent: 198 18 964 (1999-11-01), None
patent: WO-96/11929 (1996-04-01), None
patent: WO-98/09946 (1998-03-01), None
patent: WO-02/34747 (2002-05-01), None
Armin Hatzelmann & Christian Schudt, Anti-Inflammatory and Immunomodulatory Potential of the Novel PDE4 Inhibitor Roflumilast in vitro, The Journal of Pharmacology and Experimental Therapeutics, 297:267-279, 2001.
Milano, Active Drug Metabolites, Clinical Pharmacokinetics 10:216-227 (1985).
Hulme, et al. “Orally Active Indole N-Oxide PDE4 Inhibitors”, Bioorganic and Medicinal Chemistry Letters (1998). 8, 3053-3058).
Egerland Ute
Höfgen Nobert
Kuss Hildegard
Olbrich Matthias
Rundfeldt Chris
Davis Zinna N.
Elbion AG
Fulbright & Jaworski L.L.P.
LandOfFree
7-azaindoles and the use thereof as therapeutic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 7-azaindoles and the use thereof as therapeutic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 7-azaindoles and the use thereof as therapeutic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3808467