7-Azabenzimidazoles with basic side chains and use thereof

Details 7-Azabenzimidazoles with basic side chains and use thereof 7-Azabenzimidazoles with basic side chains and use thereof

1979-01-15

1981-01-27

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602444, 42424852, 42424854, 42424856, 42424857, 424250, 424251, 544 63, 544 96, 544127, 544238, 544333, 544362, 546118, A61K 3144, C07D47104

Patent

active

042475562

ABSTRACT:
There are prepared 7-azabenzimidazoles of the formula ##STR1## where R.sub.1 and R.sub.2 are the same or different and are hydrogen, C.sub.1 -C.sub.6 -alkyl or C.sub.2 -C.sub.6 -alkanol or --NR.sub.1 R.sub.2 is a 5 to 7 membered saturated heterocyclic ring having either one nitrogen atom, one nitrogen atom and one oxygen atom or two nitrogen atoms, R.sub.3 is hydroxy, an amino group, a mono C.sub.1 -C.sub.6 -Alkylamino group, a di-C.sub.1 -C.sub.6 -alkylamino group, or a C.sub.2 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, mercapto, C.sub.1 -C.sub.6 -alkylmercapto, hydroxy or C.sub.1 -C.sub.6 -alkoxy, R.sub.5 is hydrogen or halogen and A is a C.sub.2 -C.sub.6 -alkylene group or a salt of such compound. Preferably R.sub.1 and R.sub.2 are two equal C.sub.1 -C.sub.6 -alkyl groups or --NR.sub.1 R.sub.2 is piperidino, pyrrolidino, morpholino, homopiperidino, piperazino or homopiperazino, R.sub.3 is hydroxy, mercapto, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylmercapto or C.sub.1 -C.sub.6 -alkylmino, mercapto, C.sub.1 -C.sub.6 -alkylmercapto, hydroxy or C.sub.1 -C.sub.6 -alkoxy and R.sub.5 is hydrogen and salts thereof. The compounds are useful in treating ulcers and gastritis.

REFERENCES:
patent: 2987518 (1961-06-01), Hoffmann et al.
patent: 3004978 (1961-10-01), Hunger et al.
patent: 3719683 (1973-03-01), Robison et al.
patent: 4059584 (1977-11-01), Kadin
patent: 4144341 (1979-03-01), Clark et al.
Takadi, Jap. J. Pharmac., vol. 19, (1969), pp. 418-426.
Goldenberg, Gastroenterology, vol. 69, (1975), pp. 636-640.

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