7-Aminophenylacetamido-.DELTA..sup.3 -cephem antibacterial agent

Details 7-Aminophenylacetamido-.DELTA..sup.3 -cephem antibacterial agent 7-Aminophenylacetamido-.DELTA..sup.3 -cephem antibacterial agent

1977-10-21

1980-01-15

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 26, C07D50136

Patent

active

041839250

ABSTRACT:
A series of novel 7-(D-.alpha.-aminophenylacetamido)- and 7-(D-.alpha.-hydroxyphenylacetamido)-.DELTA..sup.3 -cephem derivatives have been prepared wherein a heterocyclic thiomethyl moiety is located at the 3-position of the molecule. These compounds are useful as antibacterial agents for the treatment of diseases caused by Gram-positive and Gram-negative bacteria. Preferred members include 7-(D-.alpha.-hydroxyphenylacetamido)-3-(3-carbamoyl-1,2,4-triazol-5-yl)thi omethylceph-3-em-4-carboxylic acid and 7-(D-.alpha.-hydroxyphenylacetamido)-3-(2-carboxymethoxy-methyl-1,3,4-thia diazol-5-yl)thiomethylceph-3-em-4-carboxylic acid. Alternative methods of preparation are provided for these compounds, including various synthetic routes leading to the required novel heterocyclic thiol intermediates.

REFERENCES:
patent: 3953439 (1976-04-01), Gleason
patent: 3989694 (1976-11-01), Berges
patent: 4007173 (1977-02-01), Hoover et al.
patent: 4039536 (1977-08-01), Takano et al.
patent: 4080451 (1978-03-01), Baxter et al.

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