7-(Amino or protected amino)-3-thioheterobicyclic cephalosporins

Details 7-(Amino or protected amino)-3-thioheterobicyclic cephalosporins 7-(Amino or protected amino)-3-thioheterobicyclic cephalosporins

1992-07-02

1993-09-21

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540226, 540227, C07D498053

Patent

active

052470733

ABSTRACT:
The present invention provides compounds of the formula ##STR1## wherein R.sup.0 is amino or protected amino; A and A' are taken together form a group of the formulae ##STR2## wherein X is hydrogen, halo, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, amino, nitro, carboxy; and Y is nitrogen; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4123528 (1978-10-01), Cama et al.
patent: 4500526 (1985-02-01), Imae et al.
patent: 5142039 (1992-08-01), Blaszczak et al.
Shintaro Nishimura et al., "Synthesis and Biological Activity of 3-vinylthio-and 3-vinylthiomethylcephem Derivatives", The Journal of Antibiotics, vol. XLIII, No. 9, pp. 1160-1168 (Sep. 1990).

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