7-Amino-benzocycloheptenes

Details 7-Amino-benzocycloheptenes 7-Amino-benzocycloheptenes

1976-07-26

1978-05-23

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

544398, 544403, 544401, 26029372, 26032681, 2605705R, 2605705C, 42424858, 424250, 4242484, 424267, 424274, 544174, 544178, A61K 31135, C07C 8745

Patent

active

040911152

ABSTRACT:
Novel 7-amino-benzocycloheptenes of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, chlorine, bromine and iodine in the 2- or 4-position when a halogen, Y and Z are hydrogen or together form a double bond, R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and phenyl optionally substituted with fluorine, chlorine, methyl or methoxy, R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and alkenyl of 2 to 5 carbon atoms and R.sub.2 is selected from the group consisting of alkyl of 1 to 5 carbon atoms and alkenyl of 2 to 5 carbon atoms and R.sub.1 and R.sub.2 taken together with the nitrogen atom to which they are attached form a saturated heterocycle of 4 to 6 carbon atoms and optionally containing another hetero-atom and optionally substituted with an alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressive activity and their preparation and novel intermediates.

REFERENCES:
patent: 3751420 (1973-08-01), Hauck et al.
patent: 3836534 (1974-09-01), Drukker et al.

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