7-Amino-4-trifluoromethylquinolone derived substrates and method

Details 7-Amino-4-trifluoromethylquinolone derived substrates and method 7-Amino-4-trifluoromethylquinolone derived substrates and method

1982-11-29

1985-03-19

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

045058520

ABSTRACT:
Substrates and their corresponding pharmaceutically acceptable acid salts derived from 7-amino-4-trifluoromethyl-quinolone are disclosed. These substrates are useful for determining the presence of an enzyme or enzyme inhibitor in a biological fluid, wherein the fluid is contacted with a substrate. This mixture is thereafter incubated to effect enzymatic hydrolysis. Subsequently, the presence of the free 7-amino-4-trifluoro-methylquinolone is fluorometrically detected.

REFERENCES:
patent: 4379764 (1983-04-01), Fujii et al.
patent: 4406832 (1983-09-01), Mills
patent: 4409140 (1983-10-01), Smith et al.
Chem. Abstr., vol. 84, (1976), 128535e.
J. Org. Chem., 1980, 45, 2283-2287.

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