7-amino-3-propenylcephalosporanic acid and esters thereof

Details 7-amino-3-propenylcephalosporanic acid and esters thereof 7-amino-3-propenylcephalosporanic acid and esters thereof

1986-03-25

1987-10-13

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540219, C07D50122, A61K 31545

Patent

active

046999795

ABSTRACT:
This invention provides novel cephalosporin intermediates, 7.beta.-amino-3-[(Z)-1-propen-1-y1]-3-cephem-4-carboxylic acid and esters thereof having the general formula ##STR1## wherein the configuration of the 3-propenyl group is Z sometimes referred to as cis- and R is hydrogen or a conventional carboxy-protected group, or a physiologically hydrolyzable esterifying group, and acid addition salts thereof and the metal salts of the foregoing substance wherein R is hydrogen. These compounds are useful as intermediates for preparation of orally active cephalosporins.

REFERENCES:
patent: 3769277 (1973-10-01), Long et al.
patent: 3994884 (1976-11-01), Weir
patent: 4065620 (1977-12-01), Webber
patent: 4107431 (1978-08-01), Clark et al.
patent: 4110534 (1979-08-01), Clark et al.
patent: 4409214 (1983-10-01), Takaya et al.
patent: 4520022 (1985-05-01), Hoshi et al.
H. O. House et al., J. Org. Chem. 29, 3327-3333 (Nov. 1964).

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